Temporary Hyperbilirubinemia in Two Patients During Treatment for Idiopathic Nephrotic Syndrome
نویسندگان
چکیده
Address for Correspondence:Kiyoshi Hayasaka, Department of Pediatrics, Yamagata University School of Medicine, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan We present two patients with idiopathic nephrotic syndrome who showed temporary indirect hyperbilirubinemia during the course of treatment with immunosuppressant drugs and/or steroids. We analyzed the gene of the bilirubin uridine-diphosphate glucuronosyltransferase (BUGT) and found that patient 1 was a compound heterozygote for the G71R and T-3263G mutations and patient 2 was a heterozygote for the G71R mutation. Hyperbilirubinemia should be considered as one of the adverse effects of immunosuppressant drugs and/or steroids in patients carrying the polymorphic mutations of the B-UGT gene.
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